A Practical Example for Model-Driven Web Requirements

The number of approaches for Web environments has grown very fast in the last years: HDM, OOHDM, and WSDM were among the first, and now a large number can be found in the literature. With the definition of MDA (Model- Driven Architecture) and the acceptance of MDE (Model-Driven Engineering) techniques in this environment, some groups are working in the use of metamodels and transformations to make their approaches more powerful. UWE (UMLBased Web Engineering) or OOWS (Object-Oriented Web Solutions) are only some examples. However, there are few real experiences with Web Engineering in the enterprise environment, and very few real applications of metamodels and MDE techniques. In this chapter the practical experience of a Web Engineering approach, NDT, in a big project developed in Andalusia is presented. Besides, it shows the usability of metamodels in real environments

Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats

Indexación: Web of Science; Scopus.Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared the effect of repeated stress on the expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor subunits in dorsal and ventral hippocampus (VH). Adult male Sprague-Dawley rats were randomly divided into control and stressed groups, and were daily restrained in their motion (2.5 h/day) during 14 days. We found that chronic stress promotes an increase in c-Fos mRNA levels in both hippocampal areas, although it was observed a reduction in the immunoreactivity at pyramidal cell layer. Furthermore, Arc mRNAs levels were increased in both dorsal and VH, accompanied by an increase in Arc immunoreactivity in dendritic hippocampal layers. Furthermore, stress triggered a reduction in PSD-95 and NR1 protein levels in whole extract of dorsal and VH. Moreover, a reduction in NR2A/NR2B ratio was observed only in dorsal pole. In synaptosomal fractions, we detected a rise in NR1 in dorsal hippocampus (DH). By indirect immunofluorescence we found that NR1 subunits rise, especially in neuropil areas of dorsal, but not VH. In relation to AMPA receptor (AMPAR) subunits, chronic stress did not trigger any change, either in dorsal or ventral hippocampal areas. These data suggest that DH is more sensitive than VH to chronic stress exposure, mainly altering the expression of NMDA receptor (NMDAR) subunits, and probably favors changes in the configuration of this receptor that may influence the function of this area.https://www.frontiersin.org/articles/10.3389/fnmol.2017.00244/ful

A Practical Environment to Apply Model-Driven Web Engineering

The application of a model-driven paradigm in the development of Web Systems has yielded very good research results. Several research groups are defining metamodels, transformations, and tools which offer a suitable environment, known as model-driven Web engineering (MDWE). However, there are very few practical experiences in real Web system developments using real development teams. This chapter presents a practical environment of MDWE based on the use of NDT (navigational development techniques) and Java Web systems, and it provides a practical evaluation of its application within a real project: specialized Diraya.Ministerio de Educación y Ciencia TIN2007-67843-C06-03Ministerio de Educación y Ciencia TIN2007-30391-

On the sensitivity reach of LQ production with preferential couplings to third generation fermions at the LHC

Leptoquarks (LQs) are hypothetical particles that appear in various extensions of the Standard Model (SM) that can explain observed differences between SM theory predictions and experimental results. The production of these particles has been widely studied at various experiments, most recently at the Large Hadron Collider (LHC), and stringent bounds have been placed on their masses and couplings, assuming the simplest beyond-SM (BSM) hypotheses. However, the limits are significantly weaker for LQ models with family non-universal couplings containing enhanced couplings to third-generation fermions. We present a new study on the production of a LQ at the LHC, with preferential couplings to third-generation fermions, considering proton-proton collisions at $\sqrt{s} = 13$ $\mathrm{TeV}$ and $\sqrt{s} = 13.6$ $\mathrm{TeV}$. Such a hypothesis is well motivated theoretically and it can explain the recent anomalies in the precision measurements of $\mathrm{B}$-meson decay rates, specifically the $R_{D^{(*)}}$ ratios. Under a simplified model where the LQ masses and couplings are free parameters, we focus on cases where the LQ decays to a $\tau$ lepton and a $\mathrm{b}$ quark, and study how the results are affected by different assumptions about chiral currents and interference effects with other BSM processes with the same final states, such as diagrams with a heavy vector boson, $\mathrm{Z}^{'}$. The analysis is performed using machine learning techniques, resulting in an increased discovery reach at the LHC and allowing us to probe the entirety of the new physics phase space which addresses the $\mathrm{B}$-meson anomalies, for LQ masses up to 2.25 $\mathrm{TeV}$.Comment: 26 pages, 13 figure

Physical Education Classes as a Precursor to the Mediterranean Diet and the Practice of Physical Activity

Physical activity and a healthy, balanced diet are remaining unresolved issues among young people. According to the World Health Organization, young people do not get enough exercise during the week, and physical education classes are the best way to promote healthy habits. This study aims to analyze how the role of the teacher influences the frustration of psychological needs, coping strategies, motivation, and the adoption of healthy eating habits through the Mediterranean diet and the regular practice of physical activity. The study involved 1031 boys and 910 girls between the ages of 13 and 18. To explain the relationships between the different variables included in this study, a model of structural equations has been developed. The results showed that autonomy support negatively predicted the frustration of four psychological needs. The failure to meet four psychological needs negatively predicted resilience. Likewise, resilience positively predicted autonomous motivation, and this positively predicted the Mediterranean diet and the practice of physical activity. Thus, the results obtained in the present study are in line with those of various studies wherein physical education classes were seen to help consolidate healthy living habits

Evidence of nuclear disks in starburst galaxies from their radial distribution of supernovae

Galaxy-galaxy interactions are expected to be responsible for triggering massive star formation and possibly accretion onto a supermassive black hole, by providing large amounts of dense molecular gas down to the central kiloparsec region. Several scenarios to drive the gas further down to the central ~100 pc, have been proposed, including the formation of a nuclear disk around the black hole, where massive stars would produce supernovae. Here, we probe the radial distribution of supernovae and supernova remnants in the nuclear regions of the starburst galaxies M82, Arp 299-A, and Arp 220, by using high-angular resolution (< 0."1) radio observations published in the literature (for M82 and Arp 220), or obtained by ourselves from the European VLBI Network (Arp 299-A). Our main goal was to characterize the nuclear starbursts in those galaxies and thus test scenarios that propose that nuclear disks of sizes ~100 pc form in the central regions of starburst galaxies. We obtained the radial distribution of supernovae (SNe) in the nuclear starbursts of M82, Arp 299-A, and Arp 220, and derived scale-length values for the putative nuclear disks powering the bursts in those central regions. The scale lengths for the (exponential) disks range from ~20-30 pc for Arp 299-A and Arp 220, up to ~140 pc for M82. The radial distribution of SNe for the nuclear disks in Arp 299-A and Arp 220 is also consistent with a power-law surface density profile of exponent gamma=1, as expected from detailed hydrodynamical simulations of nuclear disks. Our results support scenarios where a nuclear disk of size ~100 pc is formed in (U)LIRGs, and sustained by gas pressure, in which case the accretion onto the black hole could be lowered by supernova feedback.Comment: Accepted for publication in Astronomy and Astrophysic

Reúso de aguas residuales: impacto en los atributos químicos y macronutricionales en un suelo inceptisol irrigado con aguas residuales domésticas tratadas

(Eng) This study aimed to estimate the potential impact of wastewater reuse on the chemical and macronutritional attributes of an inceptisol cropped with sugarcane. The experimental design was in three randomized blocks, in split-plot design (three replicates per treatment), with three different irrigation treatments: treated wastewater (TWW) from Cañaveralejo wastewater treatment plant (WWTP-C); groundwater without any fertilizer (GW); and groundwater with chemical fertilizer (GW+CF). At the end of the study, plots with treated wastewater irrigation improved slightly Ca/Mg, Mg/K, and Ca+Mg/K ratios, increased OM, Na, P, and K contents and decreased pronouncedly inorganic nitrogen (N-NH4, N-NO3) of an inceptisol. Besides, we found that the type of treatment did not influence the variation of chemical attributes in soil, since statistically differences were no found in comparison among treatments. Therefore, our results suggest no adverse impact on chemical soil attributes due to wastewater reuse on sugarcane irrigation.(Spa) Este estudio tuvo como objetivo estimar el potencial impacto en los atributos químicos y macronutricionales de un suelo inceptisol sembrado con caña de azúcar y sometido a tres diferentes tratamientos de riego: Efluente de la PTAR-C (T1), Agua de Pozo (T2) y Agua de Pozo más fertilización química (T3). Se instaló un experimento en bloques completos al alzar con parcelas divididas con tres repeticiones. Al final del estudio se encontró que las relaciones de bases químicas (Ca/Mg, Mg/K, Ca+Mg/K) mejoraron en todas las parcelas, en todos los tratamientos, situación que se ratifica al no encontrarse diferencias estadísticas significativas entre los tratamientos. Así mismo, se encontró que el tipo de tratamiento no influyó en la variación en los contenidos de los macronutrientes (N, P, K) del suelo. Los contenidos de materia orgánica, P, Na y K aumentaron; y disminuyeron los de nitrógeno inorgánico (N-NH4, N-NO3) independientemente del tratamiento, lo que permite inferir la no asociación de impactos adversos en el suelo por el reúso de agua residual tratada en riego de caña de azúcar

Radio monitoring of NGC 7469: Late time radio evolution of SN 2000ft and the circumnuclear starburst in NGC 7469

We present the results of an eight-year long monitoring of the radio emission from the Luminous Infrared Galaxy (LIRG) NGC 7469, using 8.4 GHz Very Large Array (VLA) observations at 0.3'' resolution. Our monitoring shows that the late time evolution of the radio supernova SN 2000ft follows a decline very similar to that displayed at earlier times of its optically thin phase. The late time radio emission of SN 2000ft is therefore still being powered by its interaction with the presupernova stellar wind, and not with the interstellar medium (ISM). Indeed, the ram pressure of the presupernova wind is \rho_w v_w^2 \approx 7.6E-9 dyn/cm^2, at a supernova age of approximately 2127 days, which is significantly larger than the expected pressure of the ISM around SN 2000ft. At this age, the SN shock has reached a distance r_{sh \approx 0.06 pc, and our observations are probing the interaction of the SN with dense material that was ejected by the presupernova star about 5820 years prior to its explosion. From our VLA monitoring, we estimate that the swept-up mass by the supernova shock after about six years of expansion is \approx 0.29 M_sun, assuming an average expansion speed of the supernova of 10000 km/s. We also searched for recently exploded core-collapse supernovae in our VLA images. Apart from SN 2000ft (S_\nu \approx 1760 microJy at its peak, corresponding to 1.1E28 erg/s/Hz, we found no evidence for any other radio supernova (RSN) more luminous than \approx 6.0E26 erg/s/Hz, which suggests that no other Type IIn SN has exploded since 2000 in the circumnuclear starburst of NGC 7469.Comment: 10 pages, 5 figures, accepted for publication in MNRA

Fracturas de Astrágalo: Evaluación Clínico-Quirúrgica

Se han revisado 13 pacientes diagnosticados de fractura de astrágalo recogidos en nuestro Servicio de Urgencias y tratados quirúrgicamente en todos los casos. De ellos se ha realizado un seguimiento clínico y radiológico. En el 46% de los casos se obtuvieron resultados satisfactorios (23% excelentes y 23% buenos). Los restantes se repartieron entre regulares (38%) y malos (16%). La necrosis avascular apareció en 3 de los 13 casos, discutiéndose el origen de esta seria complicación. Siguiendo la clasificación de WEBER, los tipos de fractura más frecuentes fueron el tipo III (38%) y el II (31%). La congruencia articular postquirúrgica del astrágalo fracturado y el tiempo de demora en la cirugía que debe ser de urgencia, se muestran como factores a considerar en la evolución ulterior del "Aviators astragalus". Se discute así mismo el valor del signo de Hawkins.Areview of 13 patients diagnosed of Talus fracture has been colected in our service of trauma emergency. All of them have been managed by surgical methods and clinical and radiologically followed up. Satisfactory results wer e obtained in 46% of the cases (23%, excellents and 23%, good results). The rest wer e regular (38%) and bad (16%). Avascular necrosis was observed in 3 of the 13 cases, discussing the origin of this serious complication. The most frequent types of fracture were type III (38%) ant type II (31%) following Weber's classification. The postsurgical articular congruency of the fractured talus and the delayed time on the surgery which must be an emergency, seem to be factors to conside r in the later evolution of the "aviators astragalus". The value of Hawkins sign is also discussed